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Response to ART among adult PLHIV: a prospective study at HIV clinic Colombo

Authors:

L .I. Rajapaksa ,

Ministry of Health, LK
About L .I.

Consultant Venereologists, National STD/AIDS Control Programme

 

MBBS, MSc, MD(Com.Med)

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N. Herath,

Ministry of Health, LK
About N.

Acting Venereologists, National STD/AIDS Control Programme

 

MBBS, PgDip Ven, MD

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K. A. M. Aryaratne,

Ministry of Health, LK
About K. A. M.
Consultant Venereologists, National STD/AIDS Control Programme
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G. Weerasinghe

Ministry of Health, LK
About G.

Consultant Venereologists, National STD/AIDS Control Programme

 

MD(USSR), MSc, MD(Com.Med), FRCP(Edin)

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Abstract

Introduction: Sri Lanka has initiated ART programme in 2004. By the end of 2014 a total of 825 patients were receiving care services with 481 at the HIV clinic, Colombo. Based on WHO consolidated guidelines on ART published in 2013 the ART guideline was updated in 2014. It was decided to determine the response to ART among PLHIV managed according to the new guideline. The objective of the study was to determine the response to ART among adult PLHIV attending HIV clinic, NSACP.

 

Methods: A clinic based prospective study was carried out at the main STD/HIV clinic in Colombo to assess the clinical and laboratory response to ART. All adult PLHIV who were started on ART from 1st November 2014 to 31st October 2015 were included in the study and were followed up till end October 2016. Data was collected using interviewer administered questionnaire by trained medical officers. Laboratory data and other relevant information were extracted from patient records. Ethical clearance was obtained.

 

Results: A total of 95 patients were started ART at the HIV clinic, Colombo during this period. Majority (74%) were males with median age of 38 years. Among PLHIV 35.1% males and 24% of females were in WHO stage 3 or 4 at the time of presentation. TB was the commonest OI (10%) followed by PCP (9%). ART was started due to CD4 count< 500 cells/μl (77%), key populations (6%) and for PMTCT (5%). ART regimen had to be substituted in 7%. Adherence was satisfactory in females (88%) and males (89%). Most of the patients were on TDF+FTC+EFV regimen (67%) and this group experienced least side effects. Quality of life improved in 95%. CD4 count increased while viral load was <1000 copies/ml among 96% of those who had satisfactory adherence (n=76).

 

Conclusion: Most patients had satisfactory adherence and clinical, immunological and virological response was satisfactory. Poor adherence need to be further analyzed. Fixed dose combination TDF+FTC+EFV was the preferred first line regimen and was well tolerated by PLHIV.

How to Cite: Rajapaksa, L.I. et al., (2016). Response to ART among adult PLHIV: a prospective study at HIV clinic Colombo. Sri Lanka Journal of Sexual Health and HIV Medicine. 2, pp.20–26. DOI: http://doi.org/10.4038/joshhm.v2i0.41
Published on 27 Dec 2016.
Peer Reviewed

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